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In addition, BS patients are highly predisposed to cancers. Although recently the causative gene of BS (BLM) was identified as a DNA helicase homologue, the function of BLM in DNA replication has not been elucidated. In this study, p53 mutation and microsatellite instability in B-cell lymphomas originating from 2 sibling BS patients were investigated. In the originally developed tumor of both patients, no p53 mutation was detected. In one patient, however, after treatment by ionizing radiation the B-cell lymphoma recurred, showing a 9-bp deletion in exon 7. In lymphoma cells and an EB-virus-transformed cell line from BS lymphocytes of this patient, microsatellite instability was also detected from the reduced length of microsatellite DNA markers, although in the other patient microsatellite instability was not detected. Thus, 2 B-cell lymphomas, despite having the same BLM mutation, showed different phenotypes in terms of p53 mutation and microsatellite instability."}]},"source":{"sourceTitle":["International Journal of Cancer"],"sourceTitleAbbrev":"INT. J. 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Twenty-nine patients underwent 31 surgical procedures, and the remaining 13 patients were managed without surgery. Surgical details included 19 proximal vertebral artery obliterations (including 1 case of endovascular surgery using balloon occlusion), 9 trappings, 1 wrapping, 1 bleb clipping, and 1 bleb clipping combined with wrapping. Surprisingly, subsequent rupture occurred in 30 (71.4%) of the 42 patients. Excluding one patient with postoperative rupture, 29 patients suffered a subsequent rupture in the unsecured stage. Of these 29 patients, 19 were operated on after the subsequent rupture and 10 were not operated on because of deteriorated clinical condition (9 patients) or anatomic considerations (1 patient). Of the 30 patients that suffered a subsequent rupture, 14 died. Twelve of the deaths were directly related to the second episode of rupture. Of the 12 patients who did not suffer a subsequent rupture, 10 underwent operations and there were no operative deaths. Only one patient died as the result of the initial critical SAH. The mortality (46.7%) of the patients with subsequent rupture was significantly higher (P < 0.05) than that (8.3%) of the patients without subsequent rupture. Seventeen (56.7%) of the 30 subsequent ruptures occurred within 24 hours after the first SAH, and 24 (80%) occurred within the first week. Six (66.7%) of the 9 patients operated on within 24 hours after the first SAH and 11 (68.8%) of the 16 patients operated on within a week suffered preoperative subsequent ruptures. A time delay before surgical treatment resulted in a markedly high incidence of subsequent rupture. Compared with operative disadvantages, high mortality as the result of subsequent ruptures was devastating. Early surgical obliteration of the parent artery is advocated for unilateral vertebral artery dissecting aneurysms that occur with SAH."}]},"source":{"sourceTitle":["Neurosurgery"],"sourceTitleAbbrev":"NEUROSURGERY","issn":[{"issNnr":"0148396X"}],"volisspag":{"volume":"36","issue":"5","supplement":null,"firstPage":"905","lastPage":"913","pages":null},"articleNumber":null,"publicationYear":"1995"},"enhancement":{"descriptors":[{"descriptorType":"MED","descriptor":[{"weight":"b","mainterm":{"content":"adult"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["adult","groups by age","groups by age and sex"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"aged"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["adult","aged","groups by age","groups by age and sex"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"article"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["article","types of article","types of 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A substantial proportion of the respondents are sexually active and doing so with multiple sexual partners. Although 70% of respondents claimed they knew about STDs, not more than 16.1% of them could name any one common STD and give its signs or symptoms. Knowledge about prevention and complications of STDs was equally poor. The school teacher was the principal source of information followed by magazines/books. Among the respondents who had had an STD, only 8% had consulted in an STD clinic, 13.6 and 15.4% respectively to a Doctor and in Hospital, 43% received no treatment and another 19% had gone to chemist shops. The implication of these results together with the needs of the students are discussed."}]},"source":{"sourceTitle":["East African medical journal"],"sourceTitleAbbrev":"East Afr Med J","issn":[{"issNnr":"0012835X"}],"volisspag":{"volume":"67","issue":"10","supplement":null,"firstPage":"706","lastPage":"711","pages":null},"articleNumber":null,"publicationYear":"1990"},"enhancement":{"descriptors":[{"descriptorType":"MED","descriptor":[{"weight":"b","mainterm":{"content":"adolescent"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["adolescent","groups by age","groups by age and sex","juvenile"],"explodedFrom":null},{"weight":"a","mainterm":{"content":"Adolescents"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["adolescents"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"Africa"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["africa","eastern hemisphere","geographic 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