{"header": {"hits":1, "query":"l27050526:id"}, "results": [{"openLink":{"openUrl":"http://www-scopus-com.ucc.idm.oclc.org/scopus/openurl/document.url?sid=EMBASE&issn=00207136&id=doi:10.1002%2F%28SICI%291097-0215%2819961220%2969%3A6%3C480%3A%3AAID-IJC11%3E3.0.CO%3B2-5&atitle=Microsatellite+instability+in+B-cell+lymphoma+originating+from+Bloom+syndrome&stitle=INT.+J.+CANCER&title=International+Journal+of+Cancer&volume=69&issue=6&spage=480&epage=483&aulast=Kaneko&aufirst=Hideo&auinit=H.&aufull=Kaneko+H.&coden=IJCNA&isbn=&pages=480-483&date=1996&auinit1=H&auinitm=","openUrlGif":"","imageBasedLinkingUrl":null,"altText":"TEST May 2nd"},"itemInfo":{"kind":"regular","itemIdList":{"pii":null,"doi":"10.1002/(SICI)1097-0215(19961220)69:6<480::AID-IJC11>3.0.CO;2-5","lui":"L27050526","pui":"27050526","medl":"8980251","embase":"1997034314"},"dbCollection":[{"content":"EMBASE"},{"content":"MEDLINE"}]},"head":{"citationInfo":{"citationType":[{"content":"Article"}]},"citationTitle":{"titleText":[{"ttltext":"Microsatellite instability in B-cell lymphoma originating from Bloom syndrome"}]},"authorGroup":[{"etAl":false},{"etAl":false}],"abstracts":{"abstracts":[{"para":"Bloom syndrome (BS) is a rare autosomal recessive genetic disorder characterized by lupus-like erythematous telangiectasias of the face, sun sensitivity, stunted growth infertility and immunodeficiency. In addition, BS patients are highly predisposed to cancers. Although recently the causative gene of BS (BLM) was identified as a DNA helicase homologue, the function of BLM in DNA replication has not been elucidated. In this study, p53 mutation and microsatellite instability in B-cell lymphomas originating from 2 sibling BS patients were investigated. In the originally developed tumor of both patients, no p53 mutation was detected. In one patient, however, after treatment by ionizing radiation the B-cell lymphoma recurred, showing a 9-bp deletion in exon 7. In lymphoma cells and an EB-virus-transformed cell line from BS lymphocytes of this patient, microsatellite instability was also detected from the reduced length of microsatellite DNA markers, although in the other patient microsatellite instability was not detected. Thus, 2 B-cell lymphomas, despite having the same BLM mutation, showed different phenotypes in terms of p53 mutation and microsatellite instability."}]},"source":{"sourceTitle":["International Journal of Cancer"],"sourceTitleAbbrev":"INT. J. CANCER","issn":[{"issNnr":"00207136"}],"volisspag":{"volume":"69","issue":"6","supplement":null,"firstPage":"480","lastPage":"483","pages":null},"articleNumber":null,"publicationYear":"1996"},"enhancement":{"descriptors":[{"descriptorType":"DRG","descriptor":[{"weight":"a","mainterm":{"content":"microsatellite DNA"},"disterm":null,"drgterm":"microsatellite dna","devterm":null,"link":[{"linkTerm":"endogenous compound","subLink":null}],"ancestor":["chemicals and drugs","dna","microsatellite dna","natural products and their synthetic derivatives","nucleic acid","nucleic acids, nucleic acid components and their derivatives"],"explodedFrom":null}]},{"descriptorType":"MED","descriptor":[{"weight":"b","mainterm":{"content":"adult"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["adult","groups by age","groups by age and sex"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"article"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["article","types of article","types of article or study"],"explodedFrom":null},{"weight":"a","mainterm":{"content":"B cell lymphoma"},"disterm":"b cell lymphoma","drgterm":null,"devterm":null,"link":[{"linkTerm":"etiology","subLink":null}],"ancestor":["b cell lymphoma","diseases","hematologic disease","lymphatic system disease","lymphatic system tumor","lymphoma","lymphoproliferative disease","malignant neoplastic disease","neoplasm","neoplasms subdivided by anatomical site","nonhodgkin lymphoma","physical disease","physical disease by anatomical structure","physical disease by etiology and pathogenesis"],"explodedFrom":null},{"weight":"a","mainterm":{"content":"Bloom syndrome"},"disterm":"bloom syndrome","drgterm":null,"devterm":null,"link":[{"linkTerm":"etiology","subLink":null}],"ancestor":["abnormal body build","autosomal disorder","autosomal recessive disorder","bloom syndrome","congenital disorder","congenital disorders of the skin, skin appendages and subcutaneous tissue","congenital skin disease","diseases","genetic and familial disorders","genetic disorder","growth disorder","immunopathology","infant disease","monogenic disorder","newborn disease","photosensitivity disorder","physical disease","physical disease by anatomical structure","physical disease by body function","physical disease by developmental age","physical disease by etiology and pathogenesis","short stature","skin disease"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"clinical article"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["clinical article","clinical study","in vivo study","types of article or study","types of study"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"female"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["female","groups by age and sex","groups by sex"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"human"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["amniote","animal","ape","bilateria","catarrhini","chordata","deuterostomia","euarchontoglires","eukaryote","haplorhini","hominid","human","human versus nonhuman data","mammal","opisthokonta","organisms","placental mammals","primate","simian","tetrapod","therian","types of article or study","types of study","vertebrate"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"human cell"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["anatomical concepts","cell type","cells","human cell","human tissue, cells or cell components","in vitro study","types of article or study","types of study"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"male"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["groups by age and sex","groups by sex","male"],"explodedFrom":null},{"weight":"a","mainterm":{"content":"microsatellite instability"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["biological functions","biological phenomena and functions concerning the entire organism","genetic parameters","heredity","microsatellite instability","parameters","population genetic parameters","procedures, parameters and devices"],"explodedFrom":null},{"weight":"b","mainterm":{"content":"priority journal"},"disterm":null,"drgterm":null,"devterm":null,"link":null,"ancestor":["priority journal","types of article","types of article or study"],"explodedFrom":null}]}]},"authorList":{"authors":[{"initials":"H.","surname":"Kaneko"},{"initials":"R.","surname":"Inoue"},{"initials":"Y.","surname":"Yamada"},{"initials":"K.","surname":"Sukegawa"},{"initials":"T.","surname":"Fukao"},{"initials":"H.","surname":"Tashita"},{"initials":"T.","surname":"Teramoto"},{"initials":"K.","surname":"Kasahara"},{"initials":"T.","surname":"Takami"},{"initials":"N.","surname":"Kondo"}]}}}]}